O-allyl-L-tyrosine | GCE4All Knowledge Base

ncAA Foundational Publication Support

Young, Douglas D, Travis S Young, Michael Jahnz, Insha Ahmad, Glen Spraggon, and Peter G Schultz. (2011) 2011. “An Evolved Aminoacyl-Trna Synthetase With Atypical Polysubstrate Specificity.”. Biochemistry 50 (11): 1894-900. doi:10.1021/bi101929e.

Wang, Yane-Shih, Xinqiang Fang, Ashley L Wallace, Bo Wu, and Wenshe R Liu. (2012) 2012. “A Rationally Designed Pyrrolysyl-Trna Synthetase Mutant With A Broad Substrate Spectrum.”. Journal Of The American Chemical Society 134 (6): 2950-3. doi:10.1021/ja211972x.

Chatterjee, Abhishek, Han Xiao, Michael Bollong, Hui-Wang Ai, and Peter G Schultz. (2013) 2013. “Efficient Viral Delivery System For Unnatural Amino Acid Mutagenesis In Mammalian Cells.”. Proceedings Of The National Academy Of Sciences Of The United States Of America 110 (29): 11803-8. doi:10.1073/pnas.1309584110.

ncAA Utility

useful for thiol-ene click chemsitry

ncAA Source

Endogenous

ncAA Availability

Can be bought from https://www.sigmaaldrich.com/US/en/product/aldrich/78539

RS/tRNA Pair Usage Information

The pCNF RS functions in bacteria; The PylRS can function in both bacteria and eukaryotic systems and OmeYRS only works in eukaryotic systems.

All are available from Addgene, and it is not clear how the systems compare with each other in terms of effectiveness.