ncAA Structure (png, jpg, jpeg)
ncAA Foundational Publication Support
Lee, Yan-Jiun, M Schmidt, Jeffery M Tharp, Annemarie Weber, Amber Koenig, Hong Zheng, Jianmin Gao, Marcey L Waters, Daniel Summerer, and Wenshe R Liu. (2016) 2016. “Genetically Encoded Fluorophenylalanines Enable Insights Into The Recognition Of Lysine Trimethylation By An Epigenetic Reader.”. Chemical Communications (Cambridge, England) 52 (85): 12606-12609. doi:10.1039/c6cc05959g.
ncAA Utility
Serves as an NMR probe. Usable for probing cation-pi interactions.
ncAA Source
Exogenous - Purchased
ncAA Availability
Purchased from CombiBlocks Inc.
ncAA Synonyms
3,5-difluoro-l-phenylalanine
(2S)-2-amino-3-(3,5-difluorophenyl)propanoic acid
31105-91-6
F2F
(2S)-2-amino-3-(3,5-difluorophenyl)propanoic acid
31105-91-6
F2F
ChEBI ID
747858
ChEBI Link
PubChem Link
ncAA Additional Notes
Alternative difluorophenylalanine structure, 3,4-difluorophenylalanine (F2F') was also utilized with PylRS-AS in the 2017 Liu paper, however it was displacing additional phenylalanine residues making it non-viable.
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