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p-cyano-L-phenylalanine

p-Cyano-L-phenylalanine

ncAA Foundational Publication Support

Schultz, Kathryn C, Lubica Supekova, Youngha Ryu, Jianming Xie, Roshan Perera, and Peter G Schultz. (2006) 2006. “A Genetically Encoded Infrared Probe.”. Journal Of The American Chemical Society 128 (43): 13984-5.
Miyake-Stoner, Shigeki J, Andrew M Miller, Jared T Hammill, Jennifer C Peeler, Kenneth R Hess, Ryan A Mehl, and Scott H Brewer. (2009) 2009. “Probing Protein Folding Using Site-Specifically Encoded Unnatural Amino Acids As Fret Donors With Tryptophan.”. Biochemistry 48 (25): 5953-62. doi:10.1021/bi900426d.
Young, Douglas D, Travis S Young, Michael Jahnz, Insha Ahmad, Glen Spraggon, and Peter G Schultz. (2011) 2011. “An Evolved Aminoacyl-Trna Synthetase With Atypical Polysubstrate Specificity.”. Biochemistry 50 (11): 1894-900. doi:10.1021/bi101929e.

ncAA Usage Publications

Miyake-Stoner, Shigeki J, Andrew M Miller, Jared T Hammill, Jennifer C Peeler, Kenneth R Hess, Ryan A Mehl, and Scott H Brewer. (2009) 2009. “Probing Protein Folding Using Site-Specifically Encoded Unnatural Amino Acids As Fret Donors With Tryptophan.”. Biochemistry 48 (25): 5953-62. doi:10.1021/bi900426d.
ncAA Utility
FRET Probe (with Trp) and infrared probe
ncAA Source
Exogenous - Purchased
ncAA Availability
Can be purchased from https://www.biosynth.com/p/FC48004/167479-78-9-4-cyano-l-phenylalanine
RS/tRNA Pair Usage Information
The two RSs are nearly identical in sequence (just one residue different), and both appear to function quite well. Also, both are available from Addgene.

RS/tRNA Pair(s)

ChEBI ID
232822
ChEBI Link
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A232822&conversationCont…
PubChem Link
https://pubchem.ncbi.nlm.nih.gov/compound/6957993#section=3D-Conformer
ncAA Additional Notes
n/a