sulfo-L-tyrosine

sulfo-L-tyrosine

ncAA Foundational Publication Support

Liu, Chang C, and Peter G Schultz. (2006) 2006. “Recombinant Expression of Selectively Sulfated Proteins in Escherichia Coli”. Nature Biotechnology 24 (11): 1436-40.

ncAA Usage Publications

Parrish, Angela R, Xingyu She, Zheng Xiang, Irene Coin, Zhouxin Shen, Steven P Briggs, Andrew Dillin, and Lei Wang. (2012) 2012. “Expanding the Genetic Code of Caenorhabditis Elegans Using Bacterial Aminoacyl-TRNA Synthetase TRNA Pairs”. ACS Chemical Biology 7 (7): 1292-302. doi:10.1021/cb200542j.

ncAA Utility

Labelling of muscles (global)

Dipeptide (DanAla-‐Ala) required for uptake and bioavailability

ncAA Source

Exogenous - Synthesized

ncAA Availability

N/A

RS/tRNA Pair Usage Information

Naturally occurs in eukaryotic systems as a post-translational modification for secreted proteins

RS/tRNA Pair(s)

STyrRS

RS/tRNA Pair Development Year

2006

RS Organism of Origin

Methanocaldococcus jannaschii

2-Amino-3-(5-(dimethylamino)napthalene-1-sulfonamido) propanoic acid RS 1

RS/tRNA Pair Development Year

2012

RS Organism of Origin

Escherichia coli

ncAA Synonyms

sulfoTyr
sY

ChEBI ID

232819

ChEBI Link

https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A232656&conversationCont…

PubChem Link

https://pubchem.ncbi.nlm.nih.gov/compound/3364668

ncAA Additional Notes

Uptake by cells can be poor due to negative charge.