ncAA Structure (png, jpg, jpeg)
ncAA Foundational Publication Support
Plass, Tilman, Sigrid Milles, Christine Koehler, Carsten Schultz, and Edward A Lemke. (2011) 2011. “Genetically Encoded Copper-Free Click Chemistry.”. Angewandte Chemie (International Ed. In English) 50 (17): 3878-81. doi:10.1002/anie.201008178.
Plass, Tilman, Sigrid Milles, Christine Koehler, Jędrzej Szymański, Rainer Mueller, Manfred Wiessler, Carsten Schultz, and Edward A Lemke. (2012) 2012. “Amino Acids For Diels-Alder Reactions In Living Cells.”. Angewandte Chemie (International Ed. In English) 51 (17): 4166-70. doi:10.1002/anie.201108231.
ncAA Protocols
Nikić, Ivana, Jun Hee Kang, Gemma Estrada Girona, Iker Valle Aramburu, and Edward A Lemke. (2015) 2015. “Labeling Proteins On Live Mammalian Cells Using Click Chemistry.”. Nature Protocols 10 (5): 780-91. doi:10.1038/nprot.2015.045.
ncAA Utility
Click chemistry reactions with azides (SPAAC - strain-promoted azide–alkyne cycloaddition) and tetrazines (SPIEDAC - strain promoted inverse electron demand Diles-Alder cycloaddition)
ncAA Source
Exogenous - Purchased
ncAA Availability
Can be purchased from SiChem: catalog number SC-8001
ncAA Synonyms
SCO-L-Lysine
1309581-49-4
N6-((Cyclooct-2-yn-1-yloxy)carbonyl)-L-lysine
(2S)-2-Amino-6-(((cyclooct-2-yn-1-yloxy)carbonyl)amino)hexanoic acid
SCHEMBL12467487
CHEBI:232661
DA-77755
HY-157070
CS-0904946
N6-[(2-cyclooctyn-1-yloxy)carbonyl]-L-lysine
(2S)-2-amino-6-(cyclooct-2-yn-1-yloxycarbonylamino)hexanoic acid
1309581-49-4
N6-((Cyclooct-2-yn-1-yloxy)carbonyl)-L-lysine
(2S)-2-Amino-6-(((cyclooct-2-yn-1-yloxy)carbonyl)amino)hexanoic acid
SCHEMBL12467487
CHEBI:232661
DA-77755
HY-157070
CS-0904946
N6-[(2-cyclooctyn-1-yloxy)carbonyl]-L-lysine
(2S)-2-amino-6-(cyclooct-2-yn-1-yloxycarbonylamino)hexanoic acid
ChEBI ID
232661
PubChem Link