N6-(1-Methylcycloprop-2-enecarboxamido)lysine (CpK)

ncAA Foundational Publication Support

Yu, Zhipeng, Yanchao Pan, Zhiyong Wang, Jiangyun Wang, and Qing Lin. (2012) 2012. “Genetically Encoded Cyclopropene Directs Rapid, Photoclick-Chemistry-Mediated Protein Labeling In Mammalian Cells.”. Angewandte Chemie (International Ed. In English) 51 (42): 10600-4. doi:10.1002/anie.201205352.

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ncAA Utility

Reactive handle for ‘photo-click’

ncAA Source

Exogenous - Purchased

ncAA Availability

Can be purchased from https://shop.sichem.de/en/click-chemistry/sc-8017.html

RS/tRNA Pair(s)

CpK-RS

RS/tRNA Pair Development Year

2012

RS Organism of Origin

Methanosarcina barkeri

ChEBI ID

233069

ChEBI Link

https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A233069&conversationCont…

PubChem Link

https://pubchem.ncbi.nlm.nih.gov/compound/102343898

ncAA Additional Notes

A different Lys-based cyclopropene ncAA (N6-(((2methylcyclopro-2-ene-1-yl)carbonyl-L-Lys) has also been called CpK in the literature (see https://doi.org/10.1016/j.celrep.2020.107811 ).