GCE Publications

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2023 Genetic Encoding of Arylazopyrazole Phenylalanine for Optical Control of Translation. Chasity Janosko, Olivia Shade, Taylor Courtney, Trevor Horst, Melinda Liu, Sagar Khare, Alexander Deiters
2023 Selective Inhibition of Kinase Activity in Mammalian Cells by Bioorthogonal Ligand Tethering. Jinghao Chen, Yang Huang, Wen-Biao Gan, Yu-Hsuan Tsai
2023 Shedding light on ORAI1 channel with genetic code expansion. Sher Ali, Guolin Ma, Yubin Zhou
2023 Residue selective crosslinking of proteins through photoactivatable or proximity-enabled reactivity. Jun Liu, Bing Yang, Lei Wang
2023 Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation. Phillip Zhu, Kyle Nguyen, Aidan Estelle, Nikolai Sluchanko, Ryan Mehl, Richard Cooley
2023 Site-Specific Introduction of Bioorthogonal Handles to Nanopores by Genetic Code Expansion. Jing Yang, Kefan Wang, Shanyu Zhang, Xiaocui Zheng, Tongxiao Cui, Xian Yang, Yao Liu, Di Lu, Yuqin Wang, Xiao Tian, Panke Zhang, Shuo Huang, Ran Xie
2023 Structural basis of ubiquitin-independent PP1 complex disassembly by p97 Johannes van den Boom, Guendalina Marini, Hemmo Meyer, Helen Saibil
2023 Use of non-canonical amino acids in genetic code expansion-based therapeutics: Effects on mouse gut microbiota. Manyu Liang, Yanhong Yang, Jing Zhang, Yingjie Sun, Haixia Peng, Huawei Yi, Qin Wang, Xiaowei Gao
2023 Redesigning methionyl-tRNA synthetase for β-methionine activity with adaptive landscape flattening and experiments. Vaitea Opuu, Giuliano Nigro, Christine Lazennec-Schurdevin, Yves Mechulam, Emmanuelle Schmitt, Thomas Simonson
2023 Conformational GPCR BRET Sensors Based on Bioorthogonal Labeling of Noncanonical Amino Acids. Maria Kowalski-Jahn, Hannes Schihada, Gunnar Schulte
2023 Controlled Genetic Encoding of Unnatural Amino Acids in a Protein Nanopore. Xue-Yuan Wu, Meng-Yin Li, Shao-Jun Yang, Jie Jiang, Yi-Lun Ying, Peng Chen, Yi-Tao Long
2023 An intact amber-free HIV-1 system for in-virus protein bioorthogonal click labeling that delineates envelope conformational dynamics. Yuanyun Ao, Jonathan Grover, Yang Han, Guohua Zhong, Wenyi Qin, Dibya Ghimire, Anzarul Haque, Rajanya Bhattacharjee, Baoshan Zhang, James Arthos, Edward Lemke, Peter Kwong, Maolin Lu
2023 Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity. Bo Zhang, Jiaqi Sun, Yeshuang Yuan, Dezhong Ji, Yeting Sun, Yudong Liu, Shengjie Li, Xingxing Zhu, Xunyao Wu, Jin Hu, Qiu Xie, Ling Wu, Lulu Liu, Boyang Cheng, Yuanjie Zhang, Lingjuan Jiang, Lidan Zhao, Fei Yu, Wei Song, Min Wang, Yue Xu, Shiliang Ma, Yunyun Fei, Lihe Zhang, Demin Zhou, Xuan Zhang
2023 Archeal tRNA meets biotechnology: From vaccines to genetic code expansion. Lluís de Pouplana
2023 Autoregulation of GPCR signalling through the third intracellular loop. Fredrik Sadler, Ning Ma, Michael Ritt, Yatharth Sharma, Nagarajan Vaidehi, Sivaraj Sivaramakrishnan
2022 FRET Monitoring of a Nonribosomal Peptide Synthetase Elongation Module Reveals Carrier Protein Shuttling between Catalytic Domains. Jennifer Rüschenbaum, Wieland Steinchen, Florian Mayerthaler, Anna-Lena Feldberg, Henning Mootz
2022 Site-Specific Protein Labeling and Generation of Defined Ubiquitin-Protein Conjugates Using an Asparaginyl Endopeptidase. Maximilian Fottner, Johannes Heimgärtner, Maximilian Gantz, Rahel Mühlhofer, Timon Nast-Kolb, Kathrin Lang
2022 A Chemical Biology Primer for NMR Spectroscopists. Evan Clark, Elanor Sievers, Galia Debelouchina
2022 Spontaneous Orthogonal Protein Crosslinking via a Genetically Encoded 2-Carboxy-4-Aryl-1,2,3-Triazole. Yali Xu, Abdur Rahim, Qing Lin
2022 The Pyrrolysyl-tRNA Synthetase Activity can be Improved by a P188 Mutation that Stabilizes the Full-Length Enzyme. Chia-Chuan Cho, Lauren Blankenship, Xinyu Ma, Shiqing Xu, Wenshe Liu
2022 Expansion of the genetic code through reassignment of redundant sense codons using fully modified tRNA. Clinton McFeely, Kara Dods, Shivam Patel, Matthew Hartman
2022 Editorial: Expansion of the Genetic Code: Unnatural Amino Acids and their Applications. Subhendu Bag, Ishu Saraogi, Jiantao Guo
2022 Nucleobase-modified nucleosides and nucleotides: Applications in biochemistry, synthetic biology, and drug discovery. Anthony Berdis
2022 Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2. Brandon Liauw, Arash Foroutan, Michael Schamber, Weifeng Lu, Hamid Afsari, Reza Vafabakhsh
2022 Generating Efficient Pyrrolysyl-tRNA Synthetases for Structurally Diverse Non-Canonical Amino Acids. Savanna Avila-Crump, Marcus Hemshorn, Chloe Jones, Lea Mbengi, Kyle Meyer, Joshua Griffis, Subhashis Jana, Grace Petrina, Vinayak Pagar V, Andrew Karplus, James Petersson, John Perona, Ryan Mehl, Richard Cooley