ncAA Database
Displaying 1 - 11 of 11 results
| ncAA Name | ncAA Structure | ncAA Utility | Moderation State |
|---|---|---|---|
| 2-amino-4-phosphonobutanoic acid (nhpSer) | 
|
Used to produce proteins that mimic site-specific phosphorylation at a serine residue - where the phosphate group cannot by hydrolyzed - via genetic code expansion versus other protein phosphorylation strategies. | Published: Under Review |
| acridonylalanine | 
|
It is a blue-wavelength fluorescent probe used for monitoring conformational changes and other molecular dynamics in proteins. The 2013 and 2021 foundational publications provide information on its properties, and a 2023 paper (doi: 10.1002/pro.4633) provides examples of its use in FRET studies. | Published: Under Review |
| N6-Trifluoroacetyl-L-lysine | 
|
They are used for sites specifically studying post-translational modification acetylation events on particular lysine residues. Also be used as an F19 NMR probe. | Published: Under Review |
| Nε-acetyl-L-lysine | 
|
They are used for sites specifically studying post-translational modification acetylation events on particular lysine residues. | Published: Under Review |
| p-azido-l-phenylalanine (pAzF) | 
|
Used as a photocrosslinker, allowing for crosslinking and bioorthogonal ligation of protein. | Published: Under Review |
| p-benzoyl-l-phenylalanine | 
|
Used as a photocrosslinker, allowing for crosslinking and bioorthogonal ligation of protein. | Published: Under Review |
| phosphoserine | 
|
Used to produce site-specifically phosphorylated proteins at a serine residue via genetic code expansion versus other protein phosphorylation strategies. | Published: Under Review |
| phosphothreonine | 
|
Used to produce site-specifically phosphorylated proteins at a threonine residue via genetic code expansion versus other protein phosphorylation strategies. | Published: Under Review |
| phosphotyrosine | 
|
Used to produce site-specifically phosphorylated proteins at a tyrosine residue via genetic code expansion versus other protein phosphorylation strategies. | Published: Under Review |
| Tet2-Et | 
|
An amino acid that contains a 1,2,4,5-tetrazine-ethyl group that can be used for bioorthogonal, click-chemistry reactions (bioconjugation) when reacted with trans-cyclooctenes (TCOs) which can themselves be bound to various moieties such as PEG linkers, fluorophores, spin labels, etc.. These click reactions require no catalysts and can be carried out either in vivo or in vitro. Also, when reacted with strained TCOs (sTCOs), the reaction rates are extremely fast, achieving second order rate constants in excess of 10,000 per molar per second. | Published: Under Review |
| Tet3-butyl | 
|
An amino acid that contains a 1,2,4,5-tetrazine-butyl group that can be used for bioorthogonal, click-chemistry reactions (bioconjugation) when reacted with strained trans-cyclooctenes (which can themselves be bound to various moieties such as PEG linkers, fluorophores, spin labels, etc.) either in vivo for eukaryotic systems or in vitro. | Published: Under Review |