ncAA Structure (png, jpg, jpeg)
ncAA Foundational Publication Support
Tharp, Jeffery M, Yane-Shih Wang, Yan-Jiun Lee, Yanyan Yang, and Wenshe R Liu. (2014) 2014. “Genetic Incorporation Of Seven Ortho-Substituted Phenylalanine Derivatives.”. Acs Chemical Biology 9 (4): 884-90. doi:10.1021/cb400917a.
ncAA Utility
na
ncAA Source
Exogenous - Purchased
ncAA Availability
Can be purchased from https://www.sigmaaldrich.com/US/en/product/aldrich/ald00352
RS/tRNA Pair Usage Information
Yielded 24 mg/L GFPTAG2 when at 2 mM in E. coli using GMML media. Fidelity confirmed by MS. In LB media yielded 19 mg/L (~1 times that obtained with Phe) of GFPTAG27 having a 50/50 mix of Phe/2-MeO-Phe. Yielded 4.1 fold increase in fluorescence using HEK293T cells to produce an EGFR-GFPTAG128 when at 5 mM. No MS done.
ncAA Synonyms
2-Methoxy-L-Phenylalanine
193546-31-5
Phenylalanine, 2-methoxy-
(S)-2-Amino-3-(2-methoxyphenyl)propanoic acid
(2S)-2-AMINO-3-(2-METHOXYPHENYL)PROPANOIC ACID
DTXSID60444688
H-Phe(2-OMe)-OH
L-2-METHOXYPHENYLALANINE
o-Methoxyphenylalanin
MFCD01632036
SCHEMBL155235
193546-31-5
Phenylalanine, 2-methoxy-
(S)-2-Amino-3-(2-methoxyphenyl)propanoic acid
(2S)-2-AMINO-3-(2-METHOXYPHENYL)PROPANOIC ACID
DTXSID60444688
H-Phe(2-OMe)-OH
L-2-METHOXYPHENYLALANINE
o-Methoxyphenylalanin
MFCD01632036
SCHEMBL155235
ChEBI ID
233126
PubChem Link