ncAA Database

Displaying 1 - 25 of 40 results
ncAA Name ncAA Structure ncAA Utility Moderation State
p-acetyl-l-phenylalanine p-acetyl-l-phenylalanine Site-directed spin labeling, electron paramagnetic resonance Published: Under Review
2'-axialTCOK (TCO*) 2'-axial-TCOK Biorthogonal ligation, Click-Chemistry Published: Fully Reviewed
2-amino-4-phosphonobutanoic acid (nhpSer) nhpSer Used to produce proteins that mimic site-specific phosphorylation at a serine residue - where the phosphate group cannot by hydrolyzed - via genetic code expansion versus other protein phosphorylation strategies. Published: Fully Reviewed
3-(2-Naphthyl)-L-alanine 3-(2-Naphthyl)-L-alanine Speculated novel
stacking properties 		Published: Under Review
3-acetyl-L-phenylalanine 3-acetyl-L-phenylalanine can be used for protein ligation Published: Under Review
3-allyl-L-phenylalanine 2-Amino-3-(3-ethynylphenyl)propanoic acid useful for protein ligations Published: Under Review
3-Iodo-L-tyrosine 3-Iodo-L-tyrosine Aid protein crystal
structure deciphering 		Published: Under Review
3-nitro-L-phenylalanine 3-nitro-L-phenylalanine can quench Trp fluoresence via FRET in a distance dependent manner. May also be useful as a control for use in studies of the roles of 3-nitroTyr in protein structure-function. Published: Fully Reviewed
3-Nitro-L-tyrosine 3-Nitro-L-tyrosine 3-nitroTyr is a natural post-translational modification of proteins typically resulting from protein oxidation by peroxynitrite. It increases in many diseases and with age. Still unknown is if it can be reversed (by a denitrase) and if it has has a purposeful signaling role, or if it is only a modification associated with pathologies. It is known in some cases to contribute to disease pathology, but in most cases it is unknown how much it causes pathology vs. being a consequence of pathology. The ability to site specifically and quantitatively place 3-nitroTyr in positions in proteins that have been seen to occur in association with disease is a key tool to answer questions about its possible roles in normal physiology and disease. Published: Under Review
4'-TCOK (TCO) 4'TCO-lysine Reactive handle for IEDDA. Published: Fully Reviewed
acridonylalanine acridonylalanine It is a blue-wavelength fluorescent probe used for monitoring conformational changes and other molecular dynamics in proteins. The 2013 and 2021 foundational publications provide information on its properties, and a 2023 paper (doi: 10.1002/pro.4633) provides examples of its use in FRET studies. Published: Under Review
Azidohomoalanine Azidohomoalanine click chemistry, BONCAT (Bioorthogonal non-canonical amino-acid tagging) proteomics Published: Fully Reviewed
Azidonorleucine azidonorleucine Biorthogonal Ligation, Click Chemistry labeling with fluorescence or affinity labels. Specifically used for cell-specific proteomics studies using "bioorthogonal noncanonical amino acid tagging" (BONCAT) proteomics. Contrasts with Azidohomoalanine which does not allow cell-specific studies. Published: Fully Reviewed
endo-BCN-L-Lysine endo-BCN-L-Lysine Reactive handle for SPAAC Published: Fully Reviewed
exoBCN-Lysine exoBCN-L-Lysine Reactive handle for SPAAC Published: Fully Reviewed
l-Cys-e-Lys N6-L -Cysteinyl-L-lysine Condenses with 2-cyanobenzothiazole for protein modification. Published: Under Review
N6-Trifluoroacetyl-L-lysine Image showing the ChemDraw Structure of Nε-TrifluroAcetyl-L-lysine They are used for sites specifically studying post-translational modification acetylation events on particular lysine residues. Also be used as an F19 NMR probe. Published: Under Review
Norbornene-methoxycarbonyl-Lysine H-L-Lys(Norbornene-methoxycarbonyl)-OH Useful for click-chemistry with nitrile imines and tetrazines Published: Fully Reviewed
Norbornene-O–L-Lysine (NBO) Nε-5-Norbornene-2-yloxycarbonyl-L-lysine Reactive handle for IEDDA Published: Fully Reviewed
Nε-acetyl-L-lysine Image showing the ChemDraw Structure of Nε-Acetyl-L-lysine They are used for sites specifically studying post-translational modification acetylation events on particular lysine residues. Published: Under Review
O-3-butenyl-L-tyrosine (2S)-2-amino-3-(4-but-3-enoxyphenyl)propanoic acid n/a Published: Under Review
O-4-pentenyl-L-tyrosine O-4-pentenyl-L-tyrosine n/a Published: Under Review
O-allyl-L-tyrosine O-Allyl-L-tyrosine in E. coli expressed sfGFP2TAG at 10 mg/L using GMML media Published: Under Review
O-Methyl-L-tyrosine O-Methyl-L-tyrosine Labelling of muscles
(global)
 Published: Under Review
O-propargyl-L-tyrosine O-propargyl-L-tyrosine Reactive handle for azide-alkyne cycloaddition Published: Under Review