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3-trifluoromethyl-L-phenylalanine

3-trifluoromethyl-L-phenylalanine

ncAA Foundational Publication Support

Wang, Yane-Shih, Xinqiang Fang, Hsueh-Ying Chen, Bo Wu, Zhiyong U Wang, Christian Hilty, and Wenshe R Liu. (2013) 2013. “Genetic Incorporation Of Twelve Meta-Substituted Phenylalanine Derivatives Using A Single Pyrrolysyl-Trna Synthetase Mutant.”. Acs Chemical Biology 8 (2): 405-15. doi:10.1021/cb300512r.
ncAA Utility
Useful as an NMR probe, and is an alternative to the para-CF3-Phe ncAA.
ncAA Source
Exogenous - Purchased
ncAA Availability
Can be purchased from https://www.scbt.com/p/3-trifluoromethyl-l-phenylalanine-14464-68-7
RS/tRNA Pair Usage Information
incorporated at high levels into sfGFP2TAG (39 mg/L) with fidelity in E coli grown with 2 mM ncAA in GMML media. Also, yielded ~80 mg/L of sfGFP27TAG in LB media supplemented at 2 mM ncAA

RS/tRNA Pair(s)

ncAA Synonyms
63701-37-1
3-(Trifluoromethyl)-dl-phenylalanine
2-amino-3-(3-(trifluoromethyl)phenyl)propanoic acid
2-amino-3-[3-(trifluoromethyl)phenyl]propanoic Acid
3-trifluoromethyl-dl-phenylalanine
DL-Phenylalanine, 3-(trifluoromethyl)-
SCHEMBL44155
2-Amino-3-(3-(trifluoromethyl)phenyl)propanoicacid
3-(Trifluoromethyl)phenylalanine
DTXSID90980024
ChEBI ID
232678
ChEBI Link
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A232678
PubChem Link
https://pubchem.ncbi.nlm.nih.gov/compound/3-_Trifluoromethyl_-dl-phenylalanine