ncAA Structure (png, jpg, jpeg)
ncAA Utility
It is a blue-wavelength fluorescent probe used for monitoring conformational changes and other molecular dynamics in proteins. The 2013 and 2021 foundational publications provide information on its properties, and a 2023 paper (doi: 10.1002/pro.4633) provides examples of its use in FRET studies.
ncAA Source
Exogenous - Synthesized
ncAA Availability
Acridone is synthesized as described in 2013 foundational paper
RS/tRNA Pair Usage Information
AcdRS1 is the most recently developed RS, and in both E. coli and mammalian cells shows improved Acd encoding properties compared to the earlier developed RSs. In mammalian cells the AcdRS82 has slightly higher efficiency at higher Acd concentrations, while AcdRS1 (showing a UP50 near 18 microM) is more efficient at lower Acd concentrations
ncAA Synonyms
(2S)-2-amino-3-(9-oxo-9,10-dihydroacridin-2-yl)propanoic acid
Acd
acridon-2-yl-L-alanine
acridone
acridon-2-ylalanine
acridonyl-L-alanine
Acd
acridon-2-yl-L-alanine
acridone
acridon-2-ylalanine
acridonyl-L-alanine
ChEBI ID
195314
PDB Code
T7Q