ncAA Structure (png, jpg, jpeg)
ncAA Foundational Publication Support
Hoffmann, Jan-Erik, Tilman Plass, Ivana Nikić, Iker Valle Aramburu, Christine Koehler, Hartmut Gillandt, Edward A Lemke, and Carsten Schultz. (2015) 2015. “Highly Stable Trans-Cyclooctene Amino Acids For Live-Cell Labeling.”. Chemistry (Weinheim An Der Bergstrasse, Germany) 21 (35): 12266-70. doi:10.1002/chem.201501647.
Peng, Tao, and Howard C Hang. (2016) 2016. “Site-Specific Bioorthogonal Labeling For Fluorescence Imaging Of Intracellular Proteins In Living Cells.”. Journal Of The American Chemical Society 138 (43): 14423-14433.
ncAA Utility
Biorthogonal ligation, Click-Chemistry
ncAA Source
Exogenous - Synthesized
ncAA Availability
SiChem Catalog #SI8008
ncAA Synonyms
axial trans-cyclooct-2-ene-lysine
TCO*
TCO*A
TCO*
TCO*A
ChEBI ID
233438
ncAA Additional Notes
the 2'-axial TCOK isomer was reported to be much more stable than the 4'-TCOK isomers and the equatorial 2' isomer, and also reacts well.