ncAA Database

Displaying 26 - 50 of 64 results
ncAA Name ncAA Structure ncAA Utility Moderation State
N6-(((1R,2R)-2-azidocyclopentyloxy)carbonyl)-L-lysine (ACPK) ACPK contains reactive azido group Published: Fully Reviewed
N6-((2-azidoethoxy)carbonyl)-L-lysine(AzeoK) N6-((2-azidoethoxy)carbonyl)-L-lysine Reactive handle for azide-alkyne cycloaddition Published: Fully Reviewed
N6-(1-Methylcycloprop-2-enecarboxamido)lysine (CpK) N6-(1-Methylcycloprop-2-enecarboxamido)lysine (CpK) Reactive handle for ‘photo-click’ Published: Fully Reviewed
N6-(Benzyloxycarbonyl)-L-lysine (Z-Lys) Z-Lys n/a Published: Fully Reviewed
N6-Trifluoroacetyl-L-lysine Image showing the ChemDraw Structure of Nε-TrifluroAcetyl-L-lysine They are used for sites specifically studying post-translational modification acetylation events on particular lysine residues. Also be used as an F19 NMR probe. Published: Under Review
N6-[(2-(3-Methyl-3H-diazirin-3-yl)ethoxy)carbonyl]-L-lysine (AbK; DiAzKs) N6-[(2-(3-Methyl-3H-diazirin-3-yl)ethoxy)carbonyl]-L-lysine Introduced as a photocrosslinking agent that was aliphatic rather than aromatic giving it more flexibility. Similar in structure to DiZPK. Published: Fully Reviewed
Norbornene-methoxycarbonyl-Lysine H-L-Lys(Norbornene-methoxycarbonyl)-OH Useful for click-chemistry with nitrile imines and tetrazines Published: Fully Reviewed
Norbornene-O–L-Lysine (NBO) Nε-5-Norbornene-2-yloxycarbonyl-L-lysine Reactive handle for IEDDA Published: Fully Reviewed
Nε-acetyl-L-lysine Image showing the ChemDraw Structure of Nε-Acetyl-L-lysine They are used for sites specifically studying post-translational modification acetylation events on particular lysine residues. Published: Under Review
O-3-butenyl-L-tyrosine (2S)-2-amino-3-(4-but-3-enoxyphenyl)propanoic acid n/a Published: Under Review
O-4-pentenyl-L-tyrosine O-4-pentenyl-L-tyrosine n/a Published: Under Review
O-allyl-L-tyrosine O-Allyl-L-tyrosine useful for thiol-ene click chemsitry Published: Fully Reviewed
O-benzyl-L-serine O-benzyl-L-serine n/a Published: Under Review
O-methyl-L-tyrosine O-methyl-L-tyrosine Labelling of muscles
(global)
 Published: Under Review
o-nitro-L-phenylalanine 4-Nitro-3-phenyl-L-alanine Bioorthogonal Ligation handle Published: Under Review
O-propargyl-L-tyrosine O-propargyl-L-tyrosine Reactive handle for azide-alkyne cycloaddition Published: Under Review
O-tert-butyl-L-tyrosine (Tby) O-tert-butyl-L-tyrosine NMR tag for proteins Published: Fully Reviewed
p-amino-L-phenylalanine p-Aminophenylalanine π-donating effects, hydrogen-bonding properties, and weak basicity Published: Under Review
p-azido-L-phenylalanine (pAzF) Image showing the ChemDraw Structure of p-azido-l-phenylalanine (pAzF) Used as a photocrosslinker, allowing for crosslinking and also for bioorthogonal click-chemistry ligation of proteins via strain-promoted cycloadditions (SPAAC) with suitably functionalized molecules.

For crosslinking, short wave UV light (~280 nm) is typically used. Upon absorbing a photon, the activated intermediate can crosslink to neighboring atoms, if present. If no crosslinking is possible, it will relax to a ground state that cannot be reactivated. 		Published: Fully Reviewed
p-benzoyl-L-phenylalanine (Bpa) Image showing the ChemDraw Structure of p-benzoyl-l-phenylalanine Used as a photocrosslinker, allowing for crosslinking and bioorthogonal ligation of protein. Published: Fully Reviewed
p-boronophenylalanine p-Boronophenylalanine enabled one-step "scarless" protein purification procedure, and can be used to site-specifically label proteins using various boronic acid chemistries. Also, in second foundational paper was used in creating a fluorescent probe for peroxinitrite. Published: Fully Reviewed
p-chloro-L-phenylalanine 4-Chloro-L-phenylalanine NMR probe Published: Under Review
p-fluoro-L-phenylalanine 4-Fluorophenylalanine NMR probe Published: Under Review
p-iodo-L-phenylalanine p-Iodo-L-phenylalanine Can be used for phasing in protein crystallography. Published: Under Review
p-trifluoroacetyl-L-phenylalanine 2-Amino-3-(4-(2,2,2-trifluoroacetyl)phenyl)propanoic acid Flourescent Probe, Bioorthogonal ligation handle Published: Under Review