N6-(Benzyloxycarbonyl)-L-lysine (Z-Lys)

ncAA Foundational Publication Support

Mukai, Takahito, Takatsugu Kobayashi, Nobumasa Hino, Tatsuo Yanagisawa, Kensaku Sakamoto, and Shigeyuki Yokoyama. (2008) 2008. “Adding L-Lysine Derivatives To The Genetic Code Of Mammalian Cells With Engineered Pyrrolysyl-Trna Synthetases.”. Biochemical And Biophysical Research Communications 371 (4): 818-22. doi:10.1016/j.bbrc.2008.04.164.

ncAA Usage Publications

Mitrovich, Margaret, and Michael Vahey. (2025) 2025. “Genetically Recoding Respiratory Syncytial Virus To Visualize Nucleoprotein Dynamics And Virion Assembly.”. Acs Infectious Diseases 11 (1): 95-103. doi:10.1021/acsinfecdis.4c00321.

ncAA Utility

n/a

ncAA Source

Exogenous - Purchased

ncAA Availability

Can be purchased from https://www.sigmaaldrich.com/US/en/product/aldrich/96840

RS/tRNA Pair Usage Information

The Y306A,Y384F RS is available from Addgene in multiple plasmids, and apparently is the preferred RS, since the two RSs were generated by the same research group and only the one is present in Addgene.

RS/tRNA Pair(s)

MmPylRS(Y306A,Y384F)

RS/tRNA Pair Development Year

2008

RS Organism of Origin

Methanosarcina mazei

ZLysRS

RS/tRNA Pair Development Year

2008

RS Organism of Origin

Methanosarcina mazei

ncAA Synonyms

H-Lys(Z)-OH
N6-Cbz-L-Lysine
N-Epsilon-carbobenzyloxy-L-lysine
N6-(Benzyloxycarbonyl)-L-lysine
LysZ

ChEBI ID

233033

ChEBI Link

https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A233033&conversationCont…

PubChem Link

https://pubchem.ncbi.nlm.nih.gov/compound/1715626