ncAA Database
Displaying 26 - 29 of 29 results
| ncAA Name | ncAA Structure | ncAA Utility | Moderation State |
|---|---|---|---|
| SCO-L-Lysine | 
|
Click chemistry reactions with azides (SPAAC - strain-promoted azide–alkyne cycloaddition) and tetrazines (SPIEDAC - strain promoted inverse electron demand Diles-Alder cycloaddition) | Published: Fully Reviewed |
| Tet2-Et | 
|
An amino acid that contains a 1,2,4,5-tetrazine-ethyl group that can be used for bioorthogonal, click-chemistry reactions (bioconjugation) when reacted with trans-cyclooctenes (TCOs) which can themselves be bound to various moieties such as PEG linkers, fluorophores, spin labels, etc.. These click reactions require no catalysts and can be carried out either in vivo or in vitro. Also, when reacted with strained TCOs (sTCOs), the reaction rates are extremely fast, achieving second order rate constants in excess of 10,000 per molar per second. | Published: Under Review |
| Tet3-butyl | 
|
An amino acid that contains a 1,2,4,5-tetrazine-butyl group that can be used for bioorthogonal, click-chemistry reactions (bioconjugation) when reacted with strained trans-cyclooctenes (which can themselves be bound to various moieties such as PEG linkers, fluorophores, spin labels, etc.) either in vivo for eukaryotic systems or in vitro. | Published: Under Review |
| TmdZLys | 
|
Photo-cross-linking agent, and head to head comparison with Bpa and TmdPhe showed that TmdZLys led to successful crosslinking from more positions including those further apart, up to 15 Å. Tests were done with the GRB2 protein crosslinking with both the EGF receptor and the SHC receptor protein. | Published: Fully Reviewed |